Even the best original can be spoiled on press by conflicts with other parts of the layout.
That's because in offset printing, the plates pick up ink once per revolution. They lay it down on th paper as the paper is pulled through the press. Subject in line with each other all affected by the amount of ink on the rollers.
If one subject in line needs a less, a conflict develops that cannot be resolved on press. Such problems can only be avoided in prepress
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